Table 2

Relationships between expression of biological markersa

topo IIαKi67topo IIβp53p21bcl-2
Marker++++++++++++
MRP
 −875313410451010172712
 +321818164110181627373243191257
bcl-2
 −7764115657128181
 +3219191545921162735364321b
p21
 −2915181142102613193726
 +69751340715c517d
p53
 −271191329521913
 +131517e629971222f
topo IIβ
 −17737201
 +5106696
 ++12617g6245
Ki67
 −1063
 +271218
 ++275
  • a For topo IIα, topo IIβ, and Ki67: −, <30%; +, 30–60%; ++, >60% staining tumor cells. p53, p21, and bcl-2: −, ≤10%; +, >10% staining tumor cells. Only significant Ps (Pearson χ2 analysis) are indicated. All Ps are two-sided and were considered statistically significant at <0.05.

  • b P = 0.018.

  • c P = 0.001.

  • d P = 0.004.

  • e P = 0.019.

  • f P = 0.008.

  • g P = 0.003.