Table 4

MCM labeling indices for other tissuesa

TissuebConditionnMcm 5 (%)Mcm 2 (%)
StomachNormal430 (7–31)28 (25–41)
Carcinoma296 (93–98)Not done
ProstateNormal211 (8–14)16 (14–17)
Carcinoma338 (31–53)39 (31–59)
KidneyNormal42 (1–5)c2 (1–3)c
Carcinoma673 (60–84)77 (60–86)
BladderNormal217 (17–18)d20 (15–25)d
Noninvasive TCC262 (40–85)80 (77–82)
Invasive TCC1570 (38–96)87 (32–97)
ColonNormal443 (40–53)e62 (43–70)e
Adenoma691 (80–96)95 (80–100)
Carcinoma684 (80–95)90 (75–95)
  • a This table shows the median labeling indices (percentage of stained cells) for glandular tissues, when stained for Mcm 2 and Mcm 5. Ranges are given in parentheses. Significantly higher labeling indices were seen in dysplastic/neoplastic tissues.

  • b There were insufficient endometrial and ovarian cases for statistical analysis.

  • c Normal kidney tubules vs. renal cell carcinoma, P < 0.05 for Mcm 2 and Mcm 5.

  • d Normal bladder vs. invasive TCC, P < 0.05 for Mcm 2 and Mcm 5.

  • e Normal colon vs. adenoma, P < 0.05 for Mcm 2 and Mcm 5; adenoma vs. carcinoma, P not significant; normal colon vs. carcinoma, P < 0.05 for Mcm 2 and Mcm 5.