Table 5

Variations in labeling index according to grade of carcinomaa

Tissue (carcinoma)Grade of carcinomanMcm 5 (%)PCNA (%)Ki67 (%)
Skin (SCC)Well differentiated469 (42–85)60 (20–75)45 (10–73)
Moderately differentiated678 (70–95)70 (50–90)60 (31–70)
Poorly differentiated380 (75–95)71 (70–90)65 (50–71)
Bladder (TCC)Well differentiated238 (37–38)26 (17–34)12 (7–17)
Moderately differentiated770 (52–94)35 (10–77)52 (8–59)
Poorly differentiated576 (65–96)79 (37–85)71 (41–78)
Colon (adenocarcinoma)Well differentiated270 (67–73)61 (41–80)53 (38–68)
Moderately differentiated785 (80–95)82 (52–92)75 (19–80)
Poorly differentiated390 (80–93)74 (70–78)55 (41–79)
  • a Figures are given as median labeling indices, with ranges in parentheses. n is the number of cases examined in each category. There was a gradual increase in Mcm 5 labeling indices with loss of differentiation for each carcinoma. PCNA and Ki67 produced similar trends, but fewer cells stained with these antibodies than with antibodies against Mcm 5.