Table 1

Summary of antitumor efficacy of CEP-701-treated PADC-derived xenografts in athymic nude mice

In vivo invasivenesse
Cell lineSourceDifferentiationK-RASstatusp53statusacT/Cd %VehicleCEP-701Trkexpressionf(IHC)
Panc-1PrimaryPoorly differentiatedCodon 12Codon 27325g31+/++
BxPc3PrimaryModerately well differentiatedWild-typeCodon 220 and 26545g30+/−
AsPc1AscitesModerately well differentiatedCodon 12Codon 27327g31+++
Colo 357Metastases to colonModerately differentiatedCodon 12Wild-type38g22+++
MiaPaCa2PrimaryPoorly differentiatedCodon 12Codon 24860h21++
CFPACMetastases to liverWell differentiatedCodon 12Codon 24224133+++
  • a Redston, M. S., et al. (32) .

  • b Kalthoff, H., et al. (33) .

  • c Ruggeri, B., et al. (7) .

  • d T:C ratios (22) for s.c. xenografts were calculated using the following formula: Embedded Image where Vt refers to tumor volume on a given day (day 21) and Vo refers to the same tumor volume at the start of treatment.

  • e Momiki, S., et al. (21) .

  • f Miknyoczki, S. J. et al. (15) . For Trk IHC staining, −, negative, immunostaining intensity equal to tissue control; (+/−, immunostaining intensity greater than control but limited to <25% of the cells; +, moderate immunostaining intensity relative to tissue control but limited to <50% of the cells;   ++ (+++), strong-intense immunostaining relative to tissue control and present in >50% of the cells.

  • g CEP-701-treated tumors showed a statistically significant reduction in tumor volume as compared with vehicle-treated controls. P < 0.01 using Student-Newman-Keuls method or Mann-Whitney rank-sum test.

  • h CEP-701-treated tumors showed a statistically significant reduction in tumor volume as compared with vehicle-treated controls. P < 0.05 using Student-Newman-Keuls method or Mann-Whitney rank-sum test.