Survival of HT29 and LoVo cells exposed to different TAX concentrations for various times
Culture medium with TAX was changed after 48 h. Values expressed are percentages of total cells. | ||||||||||||||||||||||||||||||||
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Exposure to TAX (h) | HT29 | LoVo | ||||||||||||||||||||||||||||||
TAX doses (nm) | IC50 (nm) | TAX doses (nm) | IC50 (nm) | |||||||||||||||||||||||||||||
0.5 | 1 | 5 | 10 | 50 | 100 | 1,000 | 1 | 5 | 10 | 50 | 100 | 1,000 | 10,000 | |||||||||||||||||||
24 | 100a | 95 | 69 | 51 | 28 | 7 | 7 | 10 | 100 | 100 | 97 | 67 | 58 | 39 | 6 | 400 | ||||||||||||||||
48 | 100 | 91 | 75 | 63 | 22 | 6 | 3 | 20 | 87 | 61 | 46 | 41 | 35 | 5 | 9 | 8 | ||||||||||||||||
72 | 100 | 100 | 95 | 71 | 21 | 8 | 0 | 25 | 91 | 73 | 53 | 48 | 37 | 3 | 5 | 34 | ||||||||||||||||
96 | 100 | 100 | 100 | 78 | 4 | 5 | 0 | 15 | 100 | 97 | 73 | 65 | 42 | 2 | 2 | 80 | ||||||||||||||||
120 | 100 | 100 | 100 | 80 | 0 | 0 | 0 | 14 | 100 | 100 | 82 | 70 | 48 | 2 | 0 | 96 |
a Data represent mean values from three separate experiments; SD <5%.