Table 2

Efficacy of rMETase on growth of human colon tumors in nude mice

rMETase (5 or 10 units/g every 8 h) was administered by i.p. injection in nude mice with human colon tumor HCT 15 or HT 29 growing s.c. There were four mice with bilateral tumors in each group. Treatment started 2 days after transplantation and was given from days-2 to -6. Tumor size and body weight were measured every 3 days. Body weight (%) was compared to day-0. The efficacy of rMETase was calculated by the tumor weight ratio of the treated group to the control group (T:C). P was calculated using the Student’s t test.GroupAgentTreatmentResults (day-12)P (comparison to control)
RouteDoseScheduleaT:C (%)BW (%)
A. Efficacy of rMETase on growth of human colon tumor HCT 15 in nude mice
APBS bufferi.p. q 8 h0.5 mlDays 2–6100120
BrMETase5 units/g23113<0.001
CrMETase10 units/g20110<0.001
B. Efficacy of rMETase on growth of human colon tumor HT 29 in nude mice
ABufferi.p. q 8 h0.5 mlDays 2–6100106
BrMETase5 units/g3192<0.001
CrMETase10 units/g2790<0.001
  • a Day-0 was the day of tumor transplantation.