A. Efficacy of the combination of rMETase and CDDP on growth of human colon tumor Colo 205 in nude mice | | | | | | | |

A | Buffer | i.p. q 8 h | 0.5 ml | Days 5–9 | 100 | 120 | |

B | rMETase | i.p. q 8 h | 5 units/g | Days 5–9 | 40 | 113 | <0.05 |

C | CDDP | i.p. once | 7 mg/kg | Day-5 | 44 | 120 | <0.05 |

D | CDDP | i.p. once | 7 mg/kg | Day-10 | 42 | 105 | <0.05 |

E | rMETase + | i.p. q 8 h | 5 units/g | Days 5–9 | | | |

| CDDP | i.p. once | 7 mg/kg | Day-5 | 8 | 104 | <0.001 |

F | rMETase + | i.p. q 8 h | 5 units/g | Days 5–9 | | | |

| CDDP | i.p. once | 7 mg/kg | Day-10 | 19 | 110 | <0.01 |

B. Efficacy of the combination of rMETase and CDDP on growth of human olon tumor SW 620 in nude mice | | | | | | | |

A | Buffer | i.p. q 8 h | 0.5 ml | Days 5–9 | 100 | 105 | |

B | rMETase | i.p. q 8 h | 5 units/g | Days 5–9 | 56 | 98 | <0.05 |

C | CDDP | i.p. once | 7 mg/kg | Day-5 | 80 | 110 | >0.05 |

D | CDDP | i.p. once | 7 mg/kg | Day-10 | 72 | 115 | >0.05 |

E | rMETase + | i.p. q 8 h | 5 units/g | Days 5–9 | | | |

| CDDP | i.p. once | 7 mg/kg | Day-5 | 25 | 96 | <0.01 |

F | rMETase + | i.p. q 8 h | 5 units/g | Days 5–9 | | | |

| CDDP | i.p. once | 7 mg/kg | Day-10 | 47 | 80 | <0.05 |