Table 1

Summary of both the toxicology and pharmacokinetics data for all animals

DoseNo. of animalsaAUC (±SD) μg/ml/minT1/2 (±SD) minPeak level (±SD) μmToxicity
100 mg4215.5 (±169.0)255.5 (±27.4)5.27 (±3.11)No
350 mg intravesical51819 (±124.5)328.4 (±6.8)18.59 (±21.95)No
350 mg intravenous23695.5 (±51.6)99.3 (±5.2)52.85 (±38.06)No
1 g2106.77 (±42.50)Yes
3.5 g125764273.6517.25Yes
  • a Two animals were reutilized for i.v. pharmacokinetic studies.