Table 2

Tumor growth delay and number and size of lung metastases in animals bearing the Lewis lung carcinoma after treatment with p.o. administered PS-341 alone or along with an anticancer chemotherapeutic agent

Tumor growth delay is the difference in days for treated tumors to reach 500 mm3 compared with untreated control tumors. Untreated control tumors reach 500 mm3 in about 12 days. Mean ± SE of 15 animals.
Tumor growth delay (days)Lung metastases on day 20, n (% large)
Treatment groupAlone+ PS-341 (0.1 mg/kg)+ MG-341 (0.03 mg/kg)Alone+ PS-341 (0.1 mg/kg)+ PS-341 (0.03 mg/kg)
Control33 (45)
PS-341, p.o., d 4–184.4 ± 0.32.8 ± 0.315 (60)18 (53)
5-Fluorouracil (30 mg/kg) i.p., d 7–113.1 ± 0.38.3 ± 0.76.6 ± 0.65.5 (45)1.5 (0)2.5 (0)
CDDP (10 mg/kg) i.p., d 74.5 ± 0.47.1 ± 0.56.6 ± 0.722 (45)9.5 (58)12 (49)
Taxol (24 mg/kg) i.v., d 7–113.4 ± 0.35.7 ± 0.55.6 ± 0.523 (30)13 (46)14 (46)
Adriamycin (1.75 mg/kg) i.p., d 7–115.8 ± 0.69.6 ± 0.88.7 ± 0.618 (36)6.5 (37)12.5 (33)
X-rays (5 × 3 Gy), d 7–114.4 ± 0.32.0 ± 0.326 (35)9 (24)