Table 3

Growth delay and number of lung metastases in animals bearing Lewis lung carcinoma after treatment of the animals with i.p. administered PS-341 and 5-fluorouracil

Tumor growth delay is the difference in days for treated tumors to reach 500 mm3 compared with untreated control tumors. Untreated control tumors reach 500 mm3 in about 12 days. Mean ± SE of 15 animals.
Treatment groupTumor growth delay (days)Mean number of lung mets
Controls31
5-Fluorouracil
 30 mg/kg, i.p., d 7–114.0 ± 0.44
 25 mg/kg, i.p., d 7–112.5 ± 0.34
 20 mg/kg, i.p., d 7–111.8 ± 0.34
PS-341
 0.1 mg/kg, i.p., d 4–181.8 ± 0.312
 0.03 mg/kg, i.p., d 4–181.6 ± 0.316
 0.01 mg/kg, i.p., d 4–180.9 ± 0.317
PS-341 (0.1 mg/kg) + 5-fluorouracil
 30 mg/kg, i.p., d 7–115.0 ± 0.42
 25 mg/kg, i.p., d 7–114.2 ± 0.32
 20 mg/kg, i.p., d 7–113.7 ± 0.31
PS-341 (0.03 mg/kg) + 5-fluorouracil
 30 mg/kg, i.p., d 7–114.9 ± 0.40
 25 mg/kg, i.p., d 7–113.6 ± 0.41.5
 20 mg/kg, i.p., d 7–113.3 ± 0.31
PS-341 (0.01 mg/kg) + 5-fluorouracil
 30 mg/kg, i.p., d 7–114.8 ± 0.40
 25 mg/kg, i.p., d 7–112.8 ± 0.31.5
 20 mg/kg, i.p., d 7–112.0 ± 0.31