Table 1

%Number of patients experiencing toxic symptoms

ToxicityaNo. of patients
Gastrointestinal
Bloating7
Abdominal cramps (1 additional patient had grade 3 abdominal cramps)6
Flatulence10
Loose stools3
More frequent stools1
Diarrhea3
Constipation5
Nausea/vomiting8/1
Heartburn1
Taste changes1
Decreased appetite3
Neurologic
Paresthesia4
Headaches (1 patient had grade 3 headaches)5
Fatigue1
Skin
Sensitivity to sun/heat6
Itching (no rash)2
Rash2
Breast tenderness2
Cardiovascular
Rapid heartbeat, chest pain2
Other7
1 dysuria
1 lipoma
1 calf cramping
1 pedal edema
1 dry mouth
1 subconjunctival hemorrhage (occurred spontaneously)
1 greenish urine
  • a There was a total of 80 episodes in 26 patients.