Table 2

%Severity of toxicity by dose and study completion status

DoseCompleted follow-up (n = 17)Withdrew (n = 9)
20 mg/dayn = 4n = 2
None30
Mild10
Moderate00
Severe02
50 mg/dayn = 4n = 2
None20
Mild02
Moderate20
Severe00
100 mg/dayn = 5n = 2
None30
Mild10
Moderate12
Severe00
125 mg two times per weekn = 4n = 3
None00
Mild32
Moderate11
Severe00
Totalan = 17n = 9
None80
Mild54
Moderate43
Severe02
  • a P = 0.025 using Fisher’s Exact test, indicating that there was less toxicity in those who completed follow-up compared with those who did not. Each patient was classified according to the most severe toxicity grade experienced by that patient.