Table 3

%Toxicity associated with treatment

ToxicityGradeTreatment group
DFMO-PCV n (%)PCV n (%)
Anemia38 (5.9)6 (4.3)
41 (0.7)0
Granulocytopenia312 (8.8)21 (15)
412 (8.8)11 (7.9)
Leukopenia321 (15.6)24 (17.1)
42 (1.5)5 (3.6)
Thrombocytopenia316 (11.8)5 (3.6)
417 (12.6)3 (2.1)
Transaminase increase31 (0.7)2 (1.4)
43 (2.2)1 (bilirubin increase) (0.7)
Ototoxicity300
400
Nausea alone3 (2.2)4 (2.9)
Vomiting7 (5.2)5 (3.6)
Diarrhea8 (5.9)0
Fatigue2 (1.5)1 (0.7)
Headache1 (0.7)1 (0.7)
CNSa2 (1.5)1 (0.7)
Infection2 (1.5)2 (1.4)
  • a CNS, central nervous system.