Table 1

%Expression and association of host T-TIL response with cellular recognition, adhesion, and costimulatory molecules expressed by B-cell DLCLs

HLA, CAM, and CSMNo. of tumors (%) positive for moleculeNo. of tumors (%) negative for moleculeMean T-TIL if molecule positiveMean T-TIL if molecule negativeT-TIL significancea
B7.156 (81%)13 (19%)15.2%10.7%P = 0.15
B7.262 (90%)7 (10%)15.3%6.1%P = 0.04b
MAS59 (84%)11 (15.7%)15.5%7.8%P = 0.02b
MCA61 (87%)9 (12.9%)14.9%10.1%P = 0.20
HLA-DR66 (94%)4 (5.7%)14.9%5.7%P = 0.0004b
HLA-DP65 (94%)4 (5.8%)14.5%8.7%P = 0.17
HLA-DQ55 (80%)14 (20.3%)15.6%9.8%P = 0.07
ICAM-155 (93%)4 (6.8%)15.6%1.6%P = 0.0004b
LFA-1a61 (88%)8 (11.6%)15.0%10.0%P = 0.22
LFA-1b44 (68%)21 (32%)14.2%14.2%P = 0.99
  • a Specific HLA, CAM, or CSM association with T-TIL (two-sample t test).

  • b Significant at the P < 0.05 level.