Table 1

Nonbreast primary cancers in multiple primary cancer families

No. of cancersaBRCA1 mutation (%)BRCA2 mutation (%)
Ovarian3225 (78.1)3 (9.4)
Nonmelanoma skin163 (18.8)1 (6.2)
Colorectal150 (0.0)3 (20.0)
Cervical81 (12.5)0 (0.0)
Endometrial81 (12.5)0 (0.0)
Thyroid71 (14.3)0 (0.0)
Leukemia51 (20.0)1 (20.0)
Lymphoma40 (0.0)0 (0.0)
Othersb154 (26.7)4 (26.7)
  • a Eleven patients had two or more nonbreast cancers; thus, the numbers of cancers does not equal the number of patients.

  • b Other primary cancers include: melanoma, brain, bladder, lung, fallopian, esophageal, pituitary, head/neck, vocal cord, bone, and Wilms’ tumor.