Table 4

%Pharmacokinetic parameters of high-dose treosulfan

Treosulfan dose (g/m2)Patient no./courseAUC (μg/ml × h)Clearance (ml/min)Terminal half-life (h)Total dose (g)Renal excretion (g)Renal elimination (%)cmax (μg/ml)aVss (liter)a
20.00125301321.70405.81487614
0221201571.7533113264320
26.00524101802.5349122578826
06/121702001.56468.01856223
06/238601122.11466.013105018
0733601292.4454112086023
32.508/140701331.46591525143013
08/226402051.7159234099624
0928601621.7255173093319
39.01143501491.77662029139017
1241301581.66682942129017
136580992.37762634166018
47.01459701312.60782228118024
1563701232.15711217164021
1656001401.74832833107016
56.01780401163.06952931152019
Meann = 16145.42.0226.919.5
±SD30.30.468.73.8
  • a cmax, maximum concentration; Vss, distribution volume.