Table 1

%FRA-1 protein expression in human thyroid tumors

Histological type of thyroid specimensNo. of positive cases/no. of cases analyzed by immunohistochemistryNo. of positive cases/no. of cases analyzed by RT-PCRa
Normal thyroid0 /120 /4
Goiters8 /223 /8b
Follicular adenomas90 /1028 /10
Follicular carcinomas12 /125 /5
Papillary carcinomas34 /3410 /10
Anaplastic carcinomas4 /4
  • a RT-PCR was performed on selected cases that were also analyzed by immunohistochemistry. The cases positive by RT-PCR were also positive by immunohistochemistry.

  • b The goiter samples positive for RT-PCR were also positive by immunohistochemical analysis. Conversely, the other five cases were negative for both the assays.