Table 2

Nuclear p16 expression related to age, FIGO stage, histological type, histological grade, DNA index, S-phase fraction, estradiol receptors, progesterone receptors, nuclear Ki-67 expression, MVDmean, and nuclear p53 and p21 expression in a population-based study of endometrial carcinoma patients

VariableCategoriesNuclear p16 expressionPa
Index < 4 n (%)Index ≥ 4 n (%)
Age (yr)≤65.013 (9.3)127 (90.7)0.04
>65.026 (17.8)120 (82.2)
FIGO stageb I22 (10.4)189 (89.6)0.014
II4 (21.1)15 (78.9)
III8 (19.0)34 (81.0)
IV5 (38.5)8 (61.5)
Histological typeEndometrioid17 (8.2)190 (91.8)<0.001
Adenoacanthoma/adenosquamous9 (18.0)41 (82.0)
Serous papillary/clear cell13 (44.8)16 (55.2)
Histological gradeHigh differentiation (grade 1)064 (100.0)<0.001
Moderate differentiation (grade 2)20 (12.3)143 (87.7)
Poor differentiation (grade 3)19 (32.2)40 (67.8)
DNA indexc≤1.006 (7.9)70 (92.1)0.001
>1.009 (36.0)16 (64.0)
S-phase fractionc,d≤15%4 (8.3)44 (91.7)NSe
>15%3 (18.8)13 (81.3)
Estradiol receptorsc≤30 fmol/mg protein18 (31.6)39 (68.4)0.001
>30 fmol/mg protein9 (9.5)86 (90.5)
Progesterone receptorsc≤60 fmol/mg protein16 (38.1)26 (61.9)<0.001
>60 fmol/mg protein11 (10.1)98 (89.9)
Ki-67 expression;c,d,f>≤35%10 (6.7)139 (93.3)<0.001
>35%14 (29.8)33 (70.2)
MVDmeanc,d,g≤9014 (9.3)136 (90.7)0.025
>9010 (21.7)36 (78.3)
p53 expressioncIndex ≤ 411 (7.1)144 (92.9)<0.001
Index > 413 (31.7)28 (68.3)
p21 expressionc,d,f≤9%10 (19.6)41 (80.4)0.06
>9%14 (9.7)131 (90.3)
  • a χ2 test.

  • b Missing FIGO stage for case.

  • c Information available about the DNA index in 101 cases. S-phase fraction in 64 cases, estradiol receptors in 152 cases, progesterone receptors in 151 cases, Ki-67 expression, MVDmean, p53, and p21 expression in 196.

  • d Upper quartile was used as the cut point for S-phase fraction, Ki-67 expression, and MVDmean, and lower quartile was used for p21 expression.

  • e NS, nonsignificant.

  • f Proportion of positive nuclei.

  • g MVDmean in counts/mm2.