Table 6

Splice junction sequences of the 23 exons of the DPD gene

Exon3′ Acceptor sitea5′ Donor sitea
1CGAGgtacggacttcgcgcc
2tttatgctgtctttagAGTACTTTgtaagtaccactgata
3tttaaatatgttgcagAATTTGAGgtaagtctgggtcacc
4ttattttatttcctagATGCCAAGgtaaattcagatttaa
5tgtattaattttgcagAACTTGAGgtatgtatgatataca
6attgatttccccgtagGTATTAAGgtaatgcctacattta
7tctcctttcttttcagTACTAAAGgtaaatgaaaaaaaca
8atattgtttcttatagATAAATAGgtgagtagtttactct
9aaatttgattacttagGTTTGCAGgtataacatattgtct
10tcctttcatcattcagGAATGGAGgtaaaatggaaccatc
11ttctgttttgttttagATGGAAAGgtacagtgctgggagc
12tcacttgttttttcagTAAAACAGgtaggcatttgccatc
13ggtttgtattttgcagTCACTAAGgtaagaaaatattatt
14tttactctttcatcagGACACAACgtaagtgtgatttaac
15gtttttcttttaaagATTGTGAGgtaatggttactttag
16cctttcttgtttaaagGATTGCAGgtaaggaccttgacag
17cgacctatttgaacagGATCGAAGgtaagaacttgacttg
18gatgtgtcttgcatagGTGGTCTGgtaggtgttgcccact
19ttctgattttgtgtagGGACCCAGgtagtcattgtgtttg
20gctctgtcttttctagGTATCAAGgtatgtgcttaaatct
21tgtgttttccttttagAAACCAAGgtaaaaattatgccaa
22cagtggctatttttagGATGCCAGgtaagaatcctgctgg
23ctatttctgtttgcagGCTA
  • a Exon and intron sequences are denoted by uppercase and lowercase letters, respectively, and the nucleotide consensus sequence of the intron adjoining the splice junctions are in bold.