Table 4

Effect of single- or multiple-dose DOX or PLED plus fractionated RT against KB xenograft tumors in nude mice. Median times to reach 3Vo and statistical analyses

GroupMedian time to 3Vo (days)
9 Gy in 3F13.2
DOX 2 mg/kg plus RT21.2
PLED 2 mg/kg plus RT30.6
DOX 0.67 mg/kg (×3) plus RT19.6
PLED 0.67 mg/kg (×3) plus RT27.6
Group P
RT vs. DOX 2 mg/kg plus RT<0.05
RT vs. PLED 2 mg/kg plus RT<0.001
RT vs. DOX 0.67 mg/kg (×3) plus RT<0.05
RT vs. PLED 0.67 mg/kg (×3) plus RT<0.001
DOX 2 mg/kg plus RT vs. PLED 2 mg/kg plus RT<0.001
DOX 0.67 m/kg (×3) plus RT vs. PLED 0.67 mg/kg (×3) plus RT<0.001
DOX 2 mg/kg plus RT vs. DOX 0.67 mg/kg (×3) plus RT>0.1
PLED 2 mg/kg plus RT vs. PLED 0.67 mg/kg (×3) plus RT>0.1