Table 6

Effect of single- or multiple-dose CDDP or PLEC plus fractionated RT against KB xenograft tumors in nude mice. Median times to reach 3Vo and statistical analyses

GroupMedian time to 3Vo (days)
9 Gy in 3F13.2
CDDP 2 mg/kg plus RT18.1
PLEC 2 mg/kg plus RT21.1
CDDP 0.67 mg/kg (×3) plus RT18.8
PLEC 0.67 mg/kg (×3) plus RT20.6
Group P
RT vs. CDDP 2 mg/kg plus RT>0.1
RT vs. PLEC 2 mg/kg plus RT<0.01
RT vs. CDDP 0.67 mg/kg (×3) plus RT>0.1
RT vs. PLEC 0.67 mg/kg (×3) plus RT<0.05
CDDP 2 mg/kg plus RT vs. PLEC 2 mg/kg plus RT0.1 > P > 0.05
CDDP 0.67 mg/kg (×3) plus RT vs. PLEC 0.67 mg/kg (×3) plus RT<0.05
CDDP 2 mg/kg plus RT vs. CDDP 0.67 mg/kg (×3) plus RT>0.1
PLEC 2 mg/kg plus RT vs. PLEC 0.67 mg/kg (×3) plus RT>0.1