Table 2

Dose dependency for lethal toxicity of ZD1839 administered with various cytotoxic agents to athymic NCR-nu mice

Cytotoxic compoundAgent MTD (mg/kg)Toxic deathsMTD
ZD1839 (mg/kg)a
05075100150200
0 /320 /280 /240/301/4150
GEM3500 /150 /152 /66 /6NDbND50
EDX450 /24ND0 /242 /152/8ND75
PTXL251 /340 /342 /83 /6NDND50
DTXL200 /180 /181 /84 /6NDND50
VNR2.50 /184 /66 /66 /6NDND<25
CDDP1.50 /220 /60 /222 /152/9ND75
CBDCA500 /330 /90 /331 /153/12ND75
DOX11 /150 /100 /153 /154/10ND75
  • a ZD1839 given (qd × 5) × 2, and cytotoxic agents given q every 3–4 days × 4.

  • b ND, not determined.