Table 5

Trough plasma concentrations of sulindac sulfone at various times during 6 months administration of sulindac sulfone twice a day, orally

The 400-mg p.o. bid dose level is not shown because subjects received varying doses over time at that dose level.

Trough plasma concentrations, μg/ml
12 h1 week2 week1 month2 month3 month4 month5 month6 month
200 mg
Mean0.6662.752.962.491.973.242.061.221.37
SD0.4551.211.661.290.712.911.330.831.41
300 mg
Mean1.083.732.892.743.754.563.573.381.94
SD1.013.682.351.522.723.484.252.341.19