Table 5

Mean pharmacokinetic parameters of ONO-4007 after repeated weekly i.v. infusions (day 29)a

PatientCmax (μg/ml)Tmax (h)AUClast (μg · h/ml)t1/2 (h)nRORT
A. 75-mg dose level (n = 5)
Mean20.81.00b122579.93.801.201.31
SD3.9448414.50.1790.0995
CV (%)19.039.518.114.97.62
B. 100-mg dose level (n = 9)
Mean39.81.04b224775.13.631.181.29
SD12.5148129.80.5180.269
CV (%)31.365.939.714.322.9
C. 125-mg dose level (n = 3)
Mean40.81.00b271982.73.501.261.33
SD7.46
CV (%)18.3
  • a Cmax, highest drug concentration observed in plasma; Tmax, time at which highest drug concentration occurs; AUClast, area under the concentration time curve for last dose; t1/2, terminal half-life; RO, rate of constant i.v. infusion; RT, turnover rate; CV, coefficient of variation.

  • b Median.