Table 2

Allelic loss in progressing and nonprogressing lesions

HyperplasiaLow-grade dysplasia
Without progressionWith progressionPWithout progressionWith progressionP
No. of lesions3365423
No. with LOHa7 (21)6 (100)0.00132 (59)23 (100)0.0001
>1 arm lost 03 (50)0.00217 (31)21 (91)<0.0001
>2 arms lost 03 (50)0.00211 (20)13 (57)0.003
LOH on 3p4/30 (13)b4/6 (67)0.01413/53 (25)14/22 (64)0.003
LOH on 9p1/32 (3)3/6 (50)0.00924/52 (46)19/23 (83)0.005
LOH on 4q0/31 (0)2/6 (33)0.0234/48 (8)6/21 (29)0.057
LOH on 8p0/31 (0)2/6 (33)0.0238/51 (15)11/21 (52)0.003
LOH on 11q1/31 (3)3/6 (33)0.0626/52 (12)9/23 (39)0.011
LOH on 13q1/32 (3)0/4 (0)12/53 (4)7/21 (33)0.002
LOH on 17p0/33 (0)2/6 (33)0.02011/54 (20)9/22 (41)0.087
LOH on 3p &/or 9p5/29 (17)6/6 (100)0.00430/54 (56)22/23 (96)0.004
LOH on 3p &/or 9p plus any other arm0/32 (0)3/6 (50)0.00215/54 (28)18/23 (78)0.0001
  • a A total of seven chromosomal arms were tested. Values in parentheses are percentages.

  • b Loss/informative cases (% loss).