Table 2

Radio-chemotherapy schedules used for the treatment of 94 locally advanced squamous cell head and neck cancers

Induction chemotherapy followed by radiotherapya (n = 38)b
Regimen A (n = 14)b
Cisplatin (100 mg/m2; day 1) and 5-fluorourical (600 mg/m2; days 1–5)
Repeated every 4 weeks for three cycles before radiotherapy
Regimen B (n = 24)b
Carboplatin (AUC5; day 1), 5-FU (600 mg/m2; days 1–5)
Methotrexate (1200 mg; day 14) and leucovorin (250 mg; day 15)
Repeated every 3 weeks for three cycles before radiotherapy
Concurrent chemoradiotherapya (n = 56)b
Regimen C (n = 24)b
Cisplatin (100 mg/m2; days 1, 21, and 42)
Regimen D (n = 32)
Carboplatin (AUC5; days 1, 28, and 56) or,
Carboplatin (AUC1; days 1–9 and days 31–39)
  • a 70 Gy of conventionally fractionated RT.

  • b Number of patients.