Table 2

Pretreatment clinical stage and biologic markers as predictors of response to tamoxifen by univariate analysis

Pretreatment ER, PgR, Ki67, SPF, ploidy, and presenting clinical stage were tested to determine their influence on primary tumor response using Fisher’s exact test (binary variables), the Mann-Whitney trend test (ordered categorical variables), and the Mann-Whitney U test (continuous variables). A, aneuploid; D, diploid. Significant variables in bold.

VariableAll (n = 54)Responders (n = 31)Nonresponders (n = 23)P
No.Median (range)No.Median (range)No.Median (range)
Tumor size54T1 T2 T3 T431T1 T2 T3 T423T1 T2 T3 T40.5
6 31 10 74 19 3 52 12 7 2
Nodes54N0 N131N0 N123N0 N10.8
44 1026 518 5
ER490 (0, 8)287 (0, 8)210 (0, 7)<0.0001
PgR520 (0, 8)314 (0, 8)210 (0, 7)0.003
Ki67 (±SD)438.2 (±8.4)275.6 (±5.4)1611.3 (±11)0.08
SPF (±SD)448.2 (±7.5)256.6 (±6)1910.2 (±s8)0.1
Ploidy47A, 22 D, 2527A, 12 D, 1520A, 10 D, 100.9