Table 3

Changes in tumor markers as predictors of response to tamoxifen by univariate analysis

The numbers of patients with change in immunocytochemical score for ER and PgR or change in ploidy with exposure to tamoxifen were analyzed using the Fisher’s exact test. Changes in SPF and Ki67 were compared between responders and nonresponders by the Student’s t test as predictors of response. Significant variables in bold.

A. VariableDayRespondersNonrespondersP
IncreaseNo increaseIncreaseNo increase
ER140616NSa
PgR14934120.02
604204NS
Ploidy14210110NS
600605NS
B. VariableDayChange in variableChange in variableP
SPF (±SD)14+0.5 (0.6)−5.2 (6.0)NS
60−3.0 (4.0)−0.4 (1.3)NS
Ki67 (±SD)14−5.0 (3.0)0.8 (2.7)0.04
605.0 (15.0)−8.5 (9.0)NS
  • a NS, nonsignificant.