Table 1

Effect of cytotoxic SST analogue AN-238, cytotoxic radical AN-201, carrier peptide RC-121, and mixture of RC-121 and AN-201 on tumor volume, tumor weight, and animal mortality in athymic nude mice bearing U-87MG human glioblastomas

TreatmentTumor volume (mm3)Tumor burdenaMortalityb
InitialFinal
Control516 ± 1724782 ± 1012117.5 ± 20.30 /5
AN-201447 ± 2143133 ± 125694.2 ± 40.51 /6
RC-121+ AN-201466.8 ± 1135200 ± 713148.1 ± 20.91 /5
AN-238535.2 ± 190867.1 ± 313.323.5 ± 8.10 /6
RC-121593.2 ± 2553769 ± 626c
RC-121 (chronically)d+ AN-238455 ± 177.3596 ± 20620.9 ± 60 /7
RC-121 (acute)e+ AN-238413.8 ± 1553054.9 ± 109792.6 ± 30.30 /5
AN-238 (days 0, 11)890.7 ± 378.1637.5 ± 248.326.2 ± 10.91 /9
AN-201 (days 0, 11)941.1 ± 304.93274.2 ± 794.9112.9 ± 25.73 /10
  • a Tumor weight (mg)/body weight (g).

  • b Number of dead animals/number of total animals.

  • c On day 15, the tumor volume of 3 of 4 animals exceeded 3500 mm3, and the animals were sacrificed. Thus, the tumor volume on day 15 is shown and no data are available on tumor burden.

  • d Mice were treated daily for 7 days with RC-121 (50 μg/day per animal s.c.) prior to the administration of AN-238 at 150 nmol/kg.

  • e Mice received RC-121 at 500 μg s.c. 4 h before the administration of AN-238 at 150 nmol/kg.