Table 1

Tissue levels of boron in rats bearing 9L tumors intracranially at 2 h after i.p. dosing of D-CDU and median survival time after neutron irradiation

D-CDUμg boron/g of tumor (mean ± SD)aμg boron/g of brain (mean ± SD)aμg boron/g of blood (mean ± SD)aMedian survival time (days)b
Untreated020
Neutrons only021
30 mg/kg+ neutrons2.3 ± 1.60.17 ± 0.121.70 ± 0.7055c
150 mg/kg+ neutrons7.43 ± 1.311.13 ± 0.236.67 ± 0.6535
  • a Boron levels were determined by DCP-AES in rats (three per group) that did not receive neutrons.

  • b Rats were exposed to neutrons 2 h after D-CDU administration (sit rats per group).

  • c Significantly different (P = 0.036) than for rats receiving neutrons only.