Table 3

Cox regression analysis of lung cancer-related survival by distribution of mutations within various domains of the p53 gene

LocationNo. of patientsCodonsHR95% CI
L2 loop13L2 = 163–1953.971.51–10.45
The other mutants1.861.07–3.22
Loops L2+ L327L2 = 163–1952.361.18–4.74
The other mutantsL3 = 236–2511.871.05–3.35
Severe flexible mutants and severe contact mutants17172, 173, 175, 176, 179, 181, 238, 245, 238, and 267 and 248 and 2824.161.93–8.97
The other mutants1.690.96–2.97
Zinc atom binding residues6176, 179, 238, and 24211.73.56–38.69
The other mutants1.861.08–3.21