Table 4

Summary of eight xenografts

SpineDuraDura2FemurSkullRibLiverSphenoid
HormonesaCABCABCAB EmcytCAB EmcytZoladex OrchiectomyOrchiectomy DES NisoralCAB EncytCAB
Chemotherapyb9-Amino- camptothecin× 2 TEE× 6 C/D/P× 19-Amino- camptothecin× 2 TEE× 6 C/D/P× 1TEE× 5 C/D/P× 3 Mitoxantrone/ prednisoneTEE× 5 C/D/P× 3 Mitoxantrone/ prednisoneAdriamycin Velban C/D/P c cycles TEE 2 cycles Mitoxantrone/ Prednisone× 2C/D/P× 4 Mitoxantrone/ Prednisone× 8 Emcyt/Etoposide× 1 Emcyt/Taxol× 1 Liarazole× 1C/D/P× 1 Mitoxantrone/ Prednisone× 5 Emcyt/Etoposide× 1 Rezulin× 1Emcyt/Etoposide× 6 C/D/P Emcyt/Taxol× 7 Mitoxantrone/ Prednisone× 3
Cell line (passages)Yes (26)Yes (20)Yes (34)Yes (43)Yes (35)Yes (29)Yes (14)No
Xenograft passage no.77444435
PSA producingYesYesYesYesYesYesYesYes
Take rate90–100%90–100%90–100%90–100%90–100%70–80%90–100%Pending
Doubling timePending10 days8 days16 days12 days30 days7 daysPending
CytoanalysisHuman male hypodiploid to hypertriploid highly transformedHuman male hypertriploid highly transformedPendingPendingPendingPendingPendingPending
  • a CAB, complete androgen blockade (e.g., LH-RH agonist and antiandrogen; Emcyt, estramustine.

  • b TEE, Taxol, Emcyt, etoposide; C/D/P, cytoxan, D.E.S., prednisone.