Table 3

Relationships between the tumor:normal ratio of protease expression and clinicopathological features in matched pairs of tumor and normal lung tissues

Pathological parameteruPASTR-3MMP-2Cathepsin LCathepsin B
MedianMinaMaxPMedianMinMaxPMedianMinMaxPMedianMinMaxPMedianMinMaxP
Histological type
Squamous cell carcinoma1.80.56.5243.611.03435.03.10.5151.72.40.568.91.90.44.6
Adenocarcinoma3.51.128.30.0558121.10.45193.30.35093.10.06.50.09271.00.61.90.09062.31.013.30.3617
Neuroendocrin2.90.63.741.023.7144.20.50.50.52.71.410.51.31.33.7
Tumor stage
T12.70.69.392.641.0144.20.50.55.51.40.610.52.21.33.7
T22.80.528.30.3108122.40.45193.30.95342.60.0151.70.49081.50.568.90.99282.00.413.30.4176
T36.72.213.1243.636.0878.92.01.03.21.50.82.31.50.81.9
T42.21.13.5266.411.0961.23.12.910.41.80.63.14.61.311.9
Lymph node status
N02.20.59.367.30.4284.50.0433b3.20.069.21.60.668.92.30.813.3
N+3.50.928.30.0625212.623.75193.32.40.5151.70.72521.40.52.70.72231.50.411.90.4821
Preoperative radiotherapy
Yes2.81.59.223.511.036.02.11.03.13.12.23.13.11.54.6
No2.80.528.30.7557151.50.45193.30.11722.70.0151.70.64341.40.568.90.21032.00.413.30.4589
Neo-adjuvant chemotherapy
Yes2.80.513.1296.211.03435.02.40.5151.71.80.53.12.21.011.9
No2.80.628.30.9828121.10.45193.30.1443.00.069.20.7971.40.668.90.92541.80.413.30.6434
Capsular rupture
Yes2.30.928.3281.336.05193.30.0373b2.90.5151.71.81.02.71.90.411.9
No2.90.513.10.962654.80.4961.22.70.069.20.5241.40.568.90.83182.00.813.30.9154
  • a Min, minimum; max, maximum.

  • b Significant difference.