Table 4

Relationships between the levels of protease expression in the 119 tumor samples and clinicopathological parameters

Pathological parameternuPASTR-3MMP-2Cathepsin LCathepsin B
MeanSEPMeanSEPMeanSEPMeanSEPMeanSEP
Histological type
Squamous cell carcinoma620.1650.0280.59220.0230.0050.28260.0690.0110.78400.0340.0060.09980.2980.0680.4012
Adenocarcinoma430.2870.0650.0200.0080.0840.0160.0320.0060.3140.073
Neuroendocrin60.0970.0560.0440.0210.0340.0120.1150.0370.4190.159
Large cell carcinoma20.3740.3460.0110.0110.1260.1030.1690.1600.3410.245
Tumor stage
T1230.2750.0790.45880.0210.0070.91540.0560.0100.71390.0320.0130.54870.2260.0830.5247
T2620.2150.0420.0230.0060.0790.0130.0490.0090.3330.065
T3150.2460.0920.0280.0100.0830.0260.0320.0120.1850.430
T4140.1000.0210.0170.0050.0630.0230.0280.0090.4090.177
Lymph node status
N0570.1950.0530.44170.0170.0070.08660.0670.0110.46690.0410.0100.99790.2700.0700.6930
N+620.2420.0330.0320.0040.0800.0130.0410.0060.3340.060
Preoperative radiotherapy
Yes80.1840.0980.74980.0220.0160.97240.0740.0040.91410.0110.0040.36470.2040.1050.6247
No1110.2200.0320.0230.0040.0780.0090.0420.0060.3090.048
Neo-adjuvant chemotherapy
Yes300.1780.0360.42760.0280.0070.35460.0680.0140.65300.0390.0100.87000.3550.1150.4747
No730.2320.0400.0200.0050.0760.0110.0420.0070.2830.044
Extranodal lymph node invasion
Yes320.3160.1050.08560.0310.0100.19990.0660.0160.56400.0370.0070.65600.3080.0840.9550
No870.1890.0250.0190.0040.0770.0100.0430.0080.3020.055