Table 1

Details of patients with primary breast cancer showing tumor-specific alterations in plasma DNA

Patient no.Age (years)ICCa BM bloodCK19 BM bloodHistologyPathology, tumor size (mm)Lymph node status (no. of +ve nodes)ERGrade
Loss of heterozygosity
149b+IDC50/193
280+ILC15ND+++2
342+IDC608/18+++2
478+++IDC654/82
556+ILC150/27++2
674++ILC37ND+++2
Microsatellite instability
751++ILC200/12+++2
852Isotype pos.IDC130/21+++2
956+++IDC160/25+++1
1077ILC22ND+++3
  • a ICC, immunocytochemistry for CK19; BM, bone marrow; ER, estrogen receptor; IDC, infiltrating ductal carcinoma; ILC, infiltrating lobular carcinoma; ND, not done.

  • b −, negative; +, positive; ++, strongly positive; +++, very strongly positive.