Table 1

Treatment schedule

Day 010,000 enzyme units m−2 (125 mg m−2) of A5B7 F(ab′)2 antibody-CPG2 conjugate in 500 ml of 0.9% saline over 2 h, 10 mg of conjugate labeled with 370 MBq of 131I were given as an i.v. bolus at the end of conjugate infusion
Day+1Infusion of SB43-gal antibody to CPG2, 7.5 mg m−2 in 500 ml of 0.9% saline over 6 h, 15 mg m−2 in 500 ml of 0.9% saline over 18 h, continued to day+4 at 8 mg m−2 in 1 liter of 0.9% saline over 24 h
Day+2CMDA prodrug 200 mg m−2 infused i.v. over 2 min in fast running 1.26% NaHCO3 (given if CPG2 enzyme levels measured in blood were <0.2 enzyme units ml−1)
Day+3 and+4Repeat day+2