Table 1

Morphological characteristics of breast tumors in BRCA1 carriers, BRCA2 carriers, non-BRCA1/2 carriers, and controls

All reviews
BRCA1BRCA2Non-BRCA1/2Controls
Cancer type
Ductal246 (78%)133 (77%)104 (73%)1120 (77%)
Lobular10 (3%)16 (9%)22 (15%)142 (10%)
Tubular5 (2%)03 (2%)56 (4%)
Mucoid3 (1%)3 (2%)04 (0.2%)
Medullary35 (11%)4 (2%)1 (1%)20 (1%)
Ductal lobular2 (1%)5 (3%)1 (1%)38 (3%)
Other13 (4%)11 (6%)11 (8%)83 (6%)
DCIS
Absent180 (57%)80 (47%)69 (49%)632 (43%)
Present134 (43%)92 (53%)73 (51%)831 (57%)
LCIS
Absent308 (98%)168 (98%)133 (94%)1382 (94%)
Present6 (2%)4 (2%)9 (6%)81 (6%)
Grade
122 (8%)21 (14%)35 (27%)280 (20%)
266 (23%)75 (49%)65 (50%)571 (41%)
3197 (69%)58 (38%)30 (23%)531 (38%)
Tubules
110 (3%)2 (1%)5 (4%)93 (7%)
235 (12%)22 (14%)33 (25%)315 (23%)
3249 (85%)133 (85%)94 (71%)986 (71%)
Pleomorphism
112 (4%)10 (6%)19 (14%)116 (8%)
270 (24%)67 (43%)63 (48%)532 (38%)
3213 (72%)80 (51%)50 (38%)747 (54%)
Mitotic count
0–471 (24%)80 (51%)84 (65%)738 (52%)
5–938 (13%)30 (19%)24 (18%)219 (16%)
10–1969 (23%)28 (18%)11 (8%)207 (15%)
20–3976 (25%)17 (11%)6 (5%)140 (10%)
40+45 (15%)2 (1%)5 (4%)103 (7%)
Lymph infiltrate
Absent101 (34%)86 (55%)76 (57%)806 (57%)
Mild159 (53%)66 (42%)49 (37%)525 (37%)
Prominent39 (13%)5 (3%)8 (6%)85 (6%)
Pushing margins
Absent154 (52%)103 (66%)101 (76%)1088 (77%)
<25%35 (12%)18 (11%)13 (10%)135 (10%)
25–75%57 (19%)20 (13%)13 (10%)123 (9%)
>75%53 (18%)16 (10%)6 (5%)70 (5%)
Solid sheets
<25%139 (46%)102 (65%)100 (76%)1003 (72%)
25–75%69 (23%)36 (23%)21 (16%)253 (18%)
>75%91 (30%)18 (12%)11 (8%)145 (10%)
Nucleoli
Absent133 (44%)88 (56%)81 (61%)788 (56%)
Present166 (56%)68 (44%)52 (39%)628 (44%)
Nuclei
Non vesicular100 (37%)66 (43%)55 (41%)518 (37%)
Vesicular173 (63%)87 (57%)78 (59%)898 (63%)
Necrosis
Absent131 (48%)121 (79%)118 (87%)1175 (83%)
Present142 (52%)32 (21%)15 (13%)241 (17%)