Table 2

Estimated odds ratios and 95% confidence limits comparing features in non-BRCA1/2 tumors with other categories

Odds ratios vs. non-BRCA1/2 (95% CI)
ControlsBRCA1BRCA2
Cancer typea
Ductal1.01.01.0
Lobular1.74 (0.87–3.48)8.23 (2.64–25.61)2.40 (0.91–6.36)
Medullary0.19 (0.03–1.17)
χ21 = 2.49χ22 = 18.74χ21 = 3.15
P < 0.0001
DCIS
Absent1.01.01.0
Present0.69 (0.45–1.07)1.22 (0.68–2.20)0.67 (0.32–1.40)
χ21 = 2.77χ21 = 0.46χ21 = 1.12
P = 0.10
LCIS
Absent1.01.01.0
Present1.06 (0.41–2.73)2.75 (0.47–1.60)2.24 (0.40–12.7)
χ21 = 0.01χ21 = 1.26χ21 = 0.83
Grade
11.01.01.0
20.63 (0.39–1.02)0.86 (0.38–1.95)0.30 (0.12–0.72)
30.30 (0.15–0.59)0.13 (0.05–0.36)0.33 (0.11–0.98)
χ21 = 10.91χ21 = 9.79χ21 = 5.70
P = 0.001P = 0.0018P = 0.017
Tubules
11.01.01.0
21.80 (0.47–6.92)1.01 (0.19–5.44)0.25 (0.03–1.93)
31.15 (0.31–4.24)0.45 (0.09–2.28)0.09 (0.01–0.78)
χ21 = 0.41χ21 = 3.81χ21 = 0.19
P = 0.05
Pleomorphism
11.01.01.0
20.51 (0.31–0.85)0.48 (0.12–1.90)0.88 (0.13–0.79)
30.26 (0.14–0.52)0.14 (0.04–0.54)0.25 (0.08–0.77)
χ21 = 13.97χ21 = 10.27χ21 = 6.88
P = 0.00018P = 0.0014P = 0.01
Mitotic count
0–41.01.01.0
5–90.73 (0.41–1.29)0.46 (0.22–0.97)0.90 (0.38–2.13)
10–190.39 (0.17–0.91)0.10 (0.03–0.30)0.46 (0.18–1.15)
20–390.34 (0.11–1.03)0.11 (0.03–0.41)0.75 (0.17–3.30)
40+0.32 (0.11–0.94)0.06 (0.02–0.24)1.38 (0.23–8.11)
χ21 = 8.70χ21 = 26.22χ21 = 0.05
P = 0.003P < 0.0001
Lymphocytic infiltrate
Absent1.01.01.0
Mild0.72 (0.45–1.15)0.32 (0.17–0.61)0.62 (0.28–1.33)
Prominent0.47 (0.18–1.22)0.13 (0.04–0.38)0.52 (0.14–1.98)
χ21 = 2.97χ21 = 18.25χ21 = 1.34
P = 0.08P = 0.0001
Pushing margins
Absent1.01.01.0
<25%0.80 (0.38–1.69)0.56 (0.22–1.39)0.61 (0.21–1.77)
25–75%1.06 (0.52–2.16)0.42 (0.19–0.72)0.75 (0.27–2.07)
>75%1.08 (0.44–2.65)0.29 (0.11–0.76)0.37 (0.10–1.39)
χ21 = 0.003χ21 = 8.11χ21 = 2.83
P = 0.004
Solid sheets
<25%1.01.01.0
25–75%0.47 (0.21–1.05)0.79 (0.33–1.93)0.89 (0.48–1.64)
>75%0.30 (0.12–0.75)1.17 (0.35–3.93)0.94 (0.40–2.20)
χ21 = 0.06χ21 = 8.04χ21 = 0.003
P = 0.0047
Nucleoli
Absent1.01.01.0
Present0.66 (0.41–1.09)0.56 (0.26–1.20)1.12 (0.54–2.31)
χ21 = 2.67χ21 = 3.23χ21 = 0.09
P = 0.10P = 0.07
Nuclei
Non vesicular1.01.01.0
Vesicular0.72 (0.43–1.21)0.69 (0.36–1.35)1.14 (0.50–2.63)
χ21 = 1.55χ21 = 1.15χ21 = 0.10
Necrosis
Absent1.01.01.0
Present0.70 (0.33–1.48)0.24 (0.10–0.59)1.22 (0.44–3.29)
χ21 = 0.88χ21 = 9.57χ21 = 0.12
P = 0.002
  • a There were too few occurrences of other tumor types for formal analysis.