Table 4

Response to Onyx-015 related to p53 gene sequence and baseline neutralizing antibody level

P based on a comparison of tumors showing a response (PR and MR) versus no response (SD and Prog).

No. of patientsTarget tumor responseP
PRMRSDProg
Baseline neutralizing antibody levels
Positive131237
Negative920520.96
p53 gene sequence
Mutant162248
Wild-type510310.53
Noninterpretable10010