Table 1

Time from treatment start (day 8) until a total tumor volumea of 600 mm3 is reached

For each comparison Wilcoxon’s two-sample test was applied.

Treatment groupT600, days median (range)P
Controls13 (8–20)
Combination (IR+ TNP-470)28.5 (7–61)
vs. controls<0.001
vs. TNP-470<0.01
vs. IR<0.02
TNP-47023 (12–36)
vs. controls<0.001
IR23.5 (5–42)
vs. controls<0.01
  • a A tumor volume of 600 mm3 was chosen as a representative size of a large tumor in exponential growth (see Fig. 1<$REFLINK> ).