Table 4

Relationship between sensitivity of xenografts to temozolomide and DNA repair or p53 phenotype

Tumor lineMGMT statusaMSH2 statusbMLH1 statuscp53 statusd
High sensitivity
Rh30++±mt/wt
Rh30c++mt/wt
BT-27++±?
NB-1771+++++?
NB-1382±++++wt
Intermediate sensitivity
NB-1643++wt/functional
NB-EB±+++wt/functional
Rh28++wt
[D283]++++mt
Low sensitivity
[D283]++++mt
Rh18++±wt/MDM2 amp
Rh66+++++?
Rh12+++++wt
BT-29+++++?
NB-1691++wt/MDM2 amp
NB-SD±++±mt
GBM2++±mt
Rh28c++wt/nonfunctional
  • a MGMT relative to CEM cell level: −,<0.05; +, 0.05–0.5; ++, >0.5.

  • b MLH-1 relative to LoVo cell level: −,<0.05; +, 0.05–0.5; ++, >0.5.

  • c MSH-2 relative to HCT116 cell level: −,<0.5; +, 0.5–1.0; ++, >1.0.

  • d wt, wild type; mt, mutant; amp, amplified; ?, not determined.