Table 3

Reference values for pharmacokinetic parameters of CPT-11 and its metabolites after an i.v. infusion of 100 mg/m2 in 90 min

CPT-11SN-38SN-38
LactoneTotalLactoneTotalSN-38 Glucuronides
Rothenberg et al.a
Cmax (nm)1154 (916–1283)2141 (1733–2516)38.2 (10.5–66.5)86.1 (29.5–118.8)
t1/2 (h)7.3 (3.9–12.3)11.5 (5.5–19.3)13.4 (7.6–19.1)17.0 (11.8–23.3)
CI (liter/h/m2)45.5 (40.7–54.1)14.7 (13.7–15.5)
AUC (nm · h)3722 (3083–4100)11377 (10783–12150)536 (364–709)924 (317–1486)
Gupta et al.b
Cl (liter/h/m2)20.3 ± 4.4
AUC (nm · h)9338 ± 1612256 ± 70693 ± 597
  • a Mean values (range) of four patients receiving 100 mg/m2 as a 90-min i.v. infusion and sampled during 50 h.

  • b Mean values (± SD) of three patients receiving 100 mg/m2 as a 90-min i.v. infusion and samped during 24 h.