Table 1

Correlation of IAP protein levels with chemosensitivity data from the NCI 60 cell screening panel

Comparison of IAP protein levels and chemosensitivity data for the 60 cell line panel (NCI) resulted in a rank-order correlation. Representative results are shown for XIAP (Table 1A)<$REFLINK> and cIAP1 (Table 1B)<$REFLINK> protein levels. Positive correlation indicates that a greater abundance of the target may be associated with sensitivity to the drug, whereas a negative correlation is indicative of more target conferring cellular resistance to the given drug. Pearson correlation coefficient and two tail Ps were used to assign possible significance to these data.

RankName of drugPearsonP (two-tail)
A. XIAP protein correlation with cytotoxic drugs
1AraC0.440.00059
2Hydrazine sulfate0.410.00123
3Emofolin sodium0.390.00211
4Cyclocytidine0.380.00296
53-Deazaguanine0.340.00835
6Flavone acetic acid0.320.01098
7Deoxyspergualin0.320.01136
8Aclacinomycin A0.310.01604
9Pyrazoloacridine0.310.01672
10Rubidazone0.300.01794
21Fludarabine-PO40.260.04168
27VP-160.240.06258
32Methotrexate0.230.06958
62Flavoperidol0.190.14559
166Tamoxifen0.020.82223
B. cIAP1 protein correlation with cytotoxic drugs
1Carboplatin−0.410.00114
2Cisplatin−0.390.00195
3Asaley−0.390.00209
8Methyl CCNUa−0.340.00740
9VP-16−0.340.00769
10Thioguanine−0.330.00946
15Bleomycin−0.310.01471
17AraC−0.310.01628
19Chlorambucil−0.300.01844
  • a ccNU, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea.