Table 3

In vivo adoptive tumor growth assay in mice inoculated with M109R-HiFR tumor cells exposed in vitro to free DOX, FTL-DOX, and Doxila

Cell treatmentFinal tumor incidenceb (%)Tumor weight (mg) median (range)
Untreated13 /20 (65%)381 (48–825)
Free DOX8 /19 (42%)239 (32–683)
Doxil10 /19 (53%)397 (13–512)
FTL-DOX2 /20 (10%)57 (27–87)
  • a Results of two experiments. DOX concentration in vitro, 10 μm.

  • b Fisher’s exact test: FTL-DOX versus untreated, P = 0.0008; FTL-DOX versus Doxil, P = 0.0057; FTL-DOX versus free DOX, P = 0.0310. All other comparisons, not significant.