Table 3

In vitro inhibition of VEGF and IL-8 protein production by C225a

ProteinC225
0 μg/ml1.25 μg/ml2.5 μg/ml5.0 μg/ml
VEGF (pg/ml)909 ± 141486 ± 11b499 ± 75455 ± 15b
IL-8 (pg/ml)326 ± 11251 ± 32b274 ± 78b255 ± 32b
  • a L3.6pl cells were cultured in the presence or absence of C225 for 48 h in 5% serum containing medium. VEGF and IL-8 were measured by ELISA. Values are the mean ± SD of triplicate cultures and have been normalized to account for cell number.

  • b For 5 μg/ml C225 versus control, P < 0.05 (unpaired Student’s t test).