Characteristics of T cells used for immunotherapy
Patient no. | Diagnosis | LN cell (no.) | Proliferation SEA/IL-2 | %CD4/%CD8, initial | %CD4/%CD8, final | %CD25, final |
---|---|---|---|---|---|---|
1 | Grade II astrocytoma | 10× 108 | 36× | 66/11 | NDa | 97 |
2 | Grade II astrocytoma | 11× 108 | 51× | 55/9 | 66/35 | 89 |
3 | Anapl. mixed | 4.9× 108 | 30× | 42/14 | 59/40 | 73 |
4 | Anapl. oligodendroglioma | 3.3× 108 | 62× | 63/8 | 64/33 | ND |
5 | Anapl. ependymoma | 1.4× 108 | 75× | 55/10 | 74/24 | 88 |
6 | Anapl. astrocytoma | 0.9× 108 | 61× | 56/6 | 62/22 | 58 |
7 | Glioblastoma multiforme | 6.5× 108 | 54× | 49/6 | 76/25 | 96 |
8 | Glioblastoma multiforme | 2.8× 108 | 40× | 45/12 | 70/29 | 96 |
9 | Glioblastoma multiforme | 2.9× 108 | 33× | 64/7 | 78/18 | 99 |
10 | Glioblastoma multiforme | 2.9× 108 | 41× | 62/8 | 77/17 | 94 |
11 | Glioblastoma multiforme | 2.3× 108 | 42× | ND | 81/20 | 98 |
12 | Glioblastoma multiforme | 1.6× 108 | 19×b | 58/7 | 72/31 | 99 |
a ND, not done; Anapl., anaplastic.
b Final proliferation after additional OKT3 stimulation and IL-2 expansion was 71×.