Table 2

Toxicity using standard NCI toxicity scoresa

ToxicityGrade (n)
1234
Local site38100
Constitutional
Fatigue9200
Flu-like symptoms8000
Fever542b0
Gastrointestinal symptoms
Abdominal discomfort3000
Nausea/Vomiting122c0
Anorexia3000
Hematologic
Anemia1000
Leukopenia/thrombocytopenia0
Hepatic function
Transaminases4230
Alkaline phosphatase2010
Total bilirubin0011
  • a Table lists most severe toxicity experienced during the first four vaccine injections.

  • b One patient with presumed pneumonia.

  • c One patient with bowel obstruction related to progressive disease.