Table 3

Antibodies to GM-CSF and PAP in sera of patients treated with APC8015 and PA2024

PatientaMaximum antibody titer to GM-CSF (time to maximum response, weeks)bMaximum antibody titer to PAP (time to maximum response, weeks)b
110,000c (16)0
220,000c (16)320 (8)
340,000 (16)0
420,000 (20)0
5320 (8)0
6640 (20)10 (4)
980c,d10 (16)
10640 (16)0
111280 (16)160 (20)
1280 (16)20 (12)
131280 (16)0
  • a Patients 7 and 8 suffered from rapidly progressive disease, and serum was not available for testing.

  • b Time to development of titer ≥10; for patients with preexisting antibodies, time to a 2-fold or larger increase in titer.

  • c Patient with preexisting antibodies to GM-CSF at titers >20.

  • d Preexisting titer was unaffected by treatment.