Hematological toxicity
| Dose level (mg/m2) | No. of patients | Leukopenia | Neutropenia | Thrombocytopenia | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | 1 | 2 | 3 | 4 | |||||||||||
| 240 | 3 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | |||||||||
| 290 | ||||||||||||||||||||||
| No prior AP RTa | 5 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | |||||||||
| Prior AP RT | 7 | 0 | 1 | 2 | 1 | 0 | 2 | 2 | 1 | 0 | 0 | 0 | 0 | |||||||||
| 320 | ||||||||||||||||||||||
| No prior AP RT | 8 | 4 | 1 | 2 | 0 | 2 | 2 | 0 | 2 | 2 | 0 | 0 | 0 | |||||||||
| Prior AP RT | 5 | 0 | 1 | 3 | 1 | 1 | 1 | 0 | 3 | 1 | 0 | 0 | 0 | |||||||||
| 340 | 6 | 0 | 2 | 0 | 1 | 1 | 0 | 0 | 3 | 2 | 1 | 0 | 0 | |||||||||
a RT, radiotherapy.