Table 1

Modified concurrent biochemotherapy regimen

DTIC, 800 mg/m2, day 1
CDDP,a 20 mg/m2/day, days 1–4
Vinblastine, 1.2 mg/m2/day, days 1–4
IFN-α-2b (Schering), 5× 106 units/m2 s.c., days 1–5, 8, 10, 12
IL-2 (Chiron), 9× 106 IU/m2/day by CIV for 4 days
G-CSF, 5 μg/kg s.c. qd days 7–16b
Zofran, 32 mg i.v. qd, Ativan 1 mg p.o./i.v. every 6 hc
Cycle every 21 days; assess response on day 42; maximum of 4 cycles
  • a CDDP, cisplatin; G-CSF, granulocyte colony-stimulating factor; qd, every day; CIV, continuous i.v.

  • b Routine after patient 7.

  • c Routine after patient 14.